MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 19879-32-4
MCE 国际站:Bavachin
产品活性:Bavachin 是从补骨脂种子中分离到的黄酮类物质,作为植物雌激素激活雌性激素受体 ERα 和 ERβ,EC50 值分别为 320 和 680 nM。
研究领域:Vitamin D Related/Nuclear Receptor
作用靶点:Estrogen Receptor/ERR
结构分类:黄酮类 | 二氢黄酮 | 酚类 | 多酚类
来源:植物 | 豆科 | 补骨脂
In Vitro: Bavachin significantly inhibits melanin synthesis and TYR activity. Bavachin (10 µM) inhibits the expression of TYR and JNK proteins, and the expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2 mRNA in A375 cells. ICI182780 and U0126 cAN significantly reverse the bavachin treatment on the protein expression levels and the mRNA expression of TYR, TRP-1, TRP-2, ERK1, ERK2 and JNK2. Bavachin accumulates lipid in a dose dependent manner in ORO staining experiments. Bavachin significantly increases the growth of preadipoctye at 10 µM compared with the control cells in MTT assay. Bavachin also increases BrdU incorporation into newly synthesized DNA during pre-adipocyte proliferation. BrdU incorporation is enhanced by insulin and further enhanced by co-treatment with insulin and bavachin at 2 and 10 µM. Bavachin activates adipogenic factors and increases PPARγ transcriptional activity in differentiated adipocytes. Bavachin enhances insulin-stimulated glucose uptake through GLUT4 translocation via Akt and AMPK pathway. BVN significantly increases both hMAO-A and hMAO-B activities. Bavachin shows ER ligand binding activity in competitive displacement of [3H] E2 from recombinant ER. The estrogenic activity of bavachin is characterized in a transient transfection system using ERα or ERβ and estrogen-responsive luciferase plasmids in CV-1 cells with an EC50 of 320 nM and 680 nM, respectively. Bavachin increases the mRNA levels of estrogen-responsive genes such as pS2 and PR, and decreases the protein level of ERα by proteasomal pathway.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Natural Product Library | Anti-Cancer Compound Library | Lipid Compound Library | Phenols Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Nuclear Receptor Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Estradiol hemihydrate | OP-1074 | GSK-4716 | LSD1/ER-IN-1 | Avobenzone | Cholesterol-13C2 | Cholesterol-18O | Diethylstilbestrol | ERB-196 | FLTX1 | Raloxifene hydrochloride | Tamoxifen | Estradiol-d2-1 | Bazedoxifene acetate | FSHR agonist 1 | Estrone sulfate sodium | GNE-502 | β-Estradiol 17-acetate | Enclomiphene | AhR modulator-1 | PAC | α-Zearalenol | SNIPER(ER)-87 | ERRα antagonist-2 | Estradiol-d2 | Cholesterol-d7 | (Rac)-Hexestrol-d4 | Cholesterol-d | (E)-4-Hydroxytamoxifen | Dihydroresveratrol
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。