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Rutaecarpine

CAS No. : 84-26-4

MCE 国际站：Rutaecarpine

产品活性：Rutaecarpine, 是吴茱萸中的生物碱，是COX-2的抑制剂，其IC₅₀值为0.28 μM。

研究领域：Immunology/Inflammation

作用靶点：COX

结构分类：生物碱  |  吲哚类生物碱  |  结构分类

来源：植物  |  芸香科  |  吴茱萸

In Vitro: Rutaecarpine has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. Rutaecarpine inhibits COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC₅₀ of 0.28 μM and 8.7 μM, respectively. It inhibits COX-2-dependent conversion of exogenous arachidonic acid to PGE₂ in a dose-dependent manner by the COX-2-transfected HEK293 cells.

In Vivo: Rutaecarpine showed in vivo anti-inflammatory activity on rat l-carrageenan induced paw edema by intraperitoneal administration. Rutaecarpine significantly decreases the number of antibody-forming cells and causes weight decrease in spleen in a dose-dependent manner. In addition, rutaecarpine administered mice exhibit reduced splenic cellularity, decreased numbers of total T cells, CD4+ cells, CD8+ cells, and B cells in spleen. IL-2, interferon and IL-10 mRNA expressions are suppressed significantly by rutaecarpine treatment. The number of CD4+IL-2+ cells is reduced significantly following administration of mice with rutaecarpine.

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