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11beta-Hydroxyprogesterone

CAS No. : 600-57-7

MCE 国际站：11beta-Hydroxyprogesterone

产品活性：11beta-Hydroxyprogesterone是11β-羟基甾类脱氢酶(11β-Hydroxysteroid dehydrogenase)的有效抑制剂; 同时在COS-7细胞中激活人类盐皮质激素受体， ED₅₀ 值为10 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：甾体类  |  结构分类

In Vitro: 11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED₅₀ of 10 nM and stimulates Ams/_sc in mpkCCD_cl4 cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770.

In Vivo: 11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors.

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