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Cholesterol myristate

CAS No. : 1989-52-2

MCE 国际站：Cholesterol myristate

产品活性：Cholesterol myristate 是中药中天然类固醇。Cholesterol myristate 与多种离子通道结合，例如 nAChR，GABAA receptor 和内向整流钾离子通道 (potassium ion channel)。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：nAChR  |  GABA Receptor  |  Potassium Channel  |  Endogenous Metabolite

结构分类：甾体类

In Vitro: Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition.

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