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CAS No. : 1405-41-0
MCE 国际站:Gentamicin sulfate
产品活性:Gentamicin sulfate 是一种具有口服活性的氨基糖苷类抗生素,抑制革兰氏阳性菌和革兰氏阴性细菌的生长并可抑制组织培养中的多种支原体菌株。Gentamicin sulfate 抑制 DNase I 活性的 IC50 值为 0.57 mM。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 其他类 | 抗生素 | 种植业研究 | 抗生素 | 畜牧业研究 | 抗生素 | 植物细胞培养 | 抗生素 | 哺乳动物细胞培养 | 抗生素 | 抗性筛选 | 结构分类
In Vitro: Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication.
Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin.
Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures.
Gentamicin is produced by various species of the genus Micromonospora.
Gentamicin C1a binds in the major groove of the A-site of the RNA.
In Vivo: Gentamicin (oral and injectable forms) exhibits effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model.
Gentamicin (0.27 g/kg) shows a significant reduction of bacteria on the foreign body in mouse.
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