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PLP (139-151)

CAS No. : 131334-43-5

MCE 国际站：PLP (139-151)

产品活性：PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 139至151氨基酸片段。用于诱导实验性自身免疫性脑脊髓炎 (EAE)。

研究领域：Others

作用靶点：Others

In Vitro: Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151).

In Vivo: PLP (139-151) can be used in animal modeling to construct autoimmune encephalomyelitis model.

PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease.

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