MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 71376-34-6
MCE 国际站:Moniliformin sodium salt
产品活性:Moniliformin sodium salt是提取自镰孢镰刀菌中的有效的霉菌毒素。
研究领域:Anti-infection
作用靶点:Fungal | Antibiotic
结构分类:酮、醛、酸 | 结构分类
In Vitro: Fusarium moniliforme NRRL 6322 produces about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. Several strains of Fusarium moniliforme produce in laboratory culture more than 800 mg of moniliformin per kg of growth substrate. Monocytes-derived macrophages exposed to moniliformin during the differentiation process present a decrease of endocytosis ability, and a decrease of CD71 and HLA-DR expression.
In Vivo: Moniliformin is less toxic to mice, with an LD50 of 20.9 mg per kg for the females and 29.1 mg per kg of body weight for the males. As in the case of the chicks, mice surviving the toxin demonstrated no ill effects; the mice or chicks that died became recumbent in 4 to 6 h after treatment and died within 24 h. In 4-day-old chicken embryos, a sharp LD50 of 2.8 μg per embryo is obtained with no overt gross teratogenic effects in the survivors. Rats treated with the highest dose of moniliformin show decreased activity followed by acute heart failure and death. The rats of the lower doses (<9mg/kg b.w.) show no signs of toxicity. The daily intake of moniliformin strongly reduces the phagocytic activity of neutrophils in all dose groups. The decrease continued in the satellite group during the follow-up period, indicating a severe impact on the immune system and a LOAEL value of 3mg/kg b.w. for moniliformin. Moniliformin is rapidly excreted into urine, ranging between 20.2 and 31.5% daily and shows no signs of accumulation. The concentration of moniliformin in faeces is less than 2%, which suggests efficient absorption from the gastrointestinal tract.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Antifungal agent 26 | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Doxorubicin-13C,d3 TFA | PC945 | Antibiotic A-33853 | Sulbactam-d2 sodium | Proanthocyanidins | Azlocillin sodium salt | Chitin synthase inhibitor 11 | Toyocamycin | Hispolon | Trifloxystrobin-d3 | SPR206 acetate | Doxycycline calcium | Staurosporine | Dihydrostreptomycin sulfate | Phenazine-1-carboxylic acid | Ciclopirox olamine | Rubropunctamine | (+)-Columbianetin acetate | WX-081 | SQ109 | Neomycin sulfate | Concanavalin A | Aminothiazole | Colistin sulfate | Amphotericin A | L-Lactic acid-2-13C1 | Griseofulvin-d3
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。