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14-Deoxy-11,12-didehydroandrographolide

CAS No. : 42895-58-9

MCE 国际站：14-Deoxy-11,12-didehydroandrographolide

产品活性：14-Deoxy-11,12-didehydroandrographolide 是 Andrographolide 的类似物。14-Deoxy-11,12-didehydroandrographolide 抑制 NF-κB 活化。

研究领域：NF-κB

作用靶点：NF-κB

结构分类：萜类  |  二萜

来源：植物  |  爵床科  |  穿心莲

In Vitro: 14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.

In Vivo: 14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.

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