MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2219-31-0
MCE 国际站:L-Canavanine sulfate
产品活性:L-Canavanine sulfate 是诱导型 NO 合酶 (NO synthase) 的选择性抑制剂。
研究领域:Immunology/Inflammation
作用靶点:NO Synthase
结构分类:酮、醛、酸
来源:植物 | 其他科
In Vitro: L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC50 values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC50 of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells in vitro. In arginine-free media, IC50 of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells.
In Vivo: Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7). L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Medicine Food Homology Compound Library | Traditional Chinese Medicine Active Compound Library | Neuroprotective Compound Library | Anti-Blood Cancer Compound Library | Angiogenesis-Related Compound Library | Food-Sourced Compound Library | Targeted Diversity Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Mitochondrial Protection Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Palmitoylglycine | Ermanin | Cistanoside A | Isophysalin A | Mifepristone-13C,d3 | Dehydroevodiamine hydrochloride | Chondroitin sulfate | N'-Nitro-D-arginine | Banoxantrone | Crocin II | L-NIL hydrochloride | L-Arginine-d7 hydrochloride | Ethyl 3,4-dihydroxybenzoate | (+)-Hannokinol | 2-Thiouracil-13C,15N2 | NOS-IN-3 | Morachalcone A | 3-Bromo-7-nitroindazole | Ethyl Caffeate | Beclometasone dipropionate | Carboxyebselen | (-)-10,11-Dihydroxyfarnesol | Cauloside C | Mifepristone-d3 | Randaiol | Atraric acid | Chloranthalactone E | Dimaprit dihydrochloride | Britannilactone diacetate | 2-Iminobiotin
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。