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CAS No. : 616-45-5
MCE 国际站:2-Pyrrolidinone
产品活性:2-Pyrrolidinone 是存在于甘蓝中的活性化合物,并显示抗癌特性。
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
结构分类:生物碱 | 吡咯类生物碱
来源:植物 | 十字花科 | 甘蓝
In Vitro: Radical scavenging activity increases with increasing the amount of 2-Pyrrolidinone. The cytotoxicity of 2-Pyrrolidinone is found to be dose and time dependent, and the effect is observed microscopically in all of the selected cancer cell lines. It is observed that 2-Pyrrolidinone has cytotoxic concentrations of 2.5 mg/mL for HeLa, 3 mg/mL for PC-3 cells at 24 h and 1.5 mg/mL for HeLa and 2 mg/mL for PC-3 cells at 48 h, respectively. The cell viability decreases with increasing concentrations of purified 2-Pyrrolidinone. After treatment with 2-Pyrrolidinone their IC50 concentrations (1.5 mg/mL and 2 mg/mL for HeLa and PC-3 cells, respectively) for a period of 24 h, morphological changes in the cells are observed. It is demonstrated that 2-Pyrrolidinone induces apoptosis in HeLa and PC-3 cells via G0/G1phase of cell cycle arrest.
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