MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 64439-81-2
MCE 国际站:(±)-10-Hydroxycamptothecin
产品活性:(±)-10-Hydroxycamptothecin 是一种生物碱,能够抑制拓扑异构酶 I (topoisomerase I) 的活性,具有广谱的抗肿瘤活性。
研究领域:Cell Cycle/DNA Damage
作用靶点:Topoisomerase
结构分类:生物碱 | 喹啉类生物碱 | 生物碱 | 吡咯类生物碱 | 酚类 | 单酚类
来源:植物 | 蓝果树科 | 喜树
In Vitro: (±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24).
In Vivo: (±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Phenols Library | Traditional Chinese Medicine Active Compound Library | Alkaloids Library | Anti-Lung Cancer Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Highly Selective Inhibitors Library | Gepotidacin | Topoisomerase IV inhibitor 2 | Phenoxodiol | Topotecan hydrochloride hydrate | NHC-triphosphate tetraammonium | Berberine | Levofloxacin sodium | TAS-103 dihydrochloride | Ciprofloxacin | Mitoxantrone diacetate | Murrayanol | Gimatecan | Camptothecin | EGFR-IN-57 | SW044248 | Topoisomerase I/II inhibitor 4 | NHC-diphosphate triammonium | Betulinic acid | ICRF-196 | 3,6-Diamino-9(10H)-acridone | Epirubicin | 12-Ethyl-9-hydroxycamptothecin | Topoisomerase II inhibitor 3 | Becatecarin | Pixantrone hydrochloride | Datopotamab deruxtecan | Isosteviol
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。