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Saikosaponin D

CAS No. : 20874-52-6

MCE 国际站：Saikosaponin D

产品活性：Saikosaponin D 是从柴胡中分离到的三萜皂苷类，具有抗炎，抗菌，抗肿瘤，抗过敏的功效；Saikosaponin D 可以抑制 selectin，STAT3 和 NF-kB 的活性，活化 estrogen receptor-β。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt  |  NF-κB  |  Vitamin D Related/Nuclear Receptor  |  Anti-infection

作用靶点：STAT  |  NF-κB  |  Estrogen Receptor/ERR  |  Bacterial

结构分类：萜类  |  三萜

来源：植物  |  唇形科  |  匍匐筋骨草  |  植物  |  伞形科

In Vitro: Saikosaponin D (Compound 3) is a triterpene saponin, which inhibits E-selectin, L-selectin and P-selectin binding to THP-1 cells, with IC₅₀s of 1.8 µM, 3.0 µM and 4.3 µM, and such effects are not due to cytotoxic action. Saikosaponin D (1, 5, 10 µM) dose-dependently inhibits the THP-1 adhesion to the HUVECs monolayer activated by TNF-α. Saikosaponin D (30 μM) also inhibits the expression of P-selectin ligand (CD162) in THP-1 cells. Saikosaponin D (5 μM) suppresses the proliferation of HSC-T6 cells induced by H₂O₂ treatment, reduces the expression levels of α-SMA, TGF-β1, Hyp, COL1 and TIMP-1, and increases MMP-1 expressioon, thus inhibiting H₂O₂-induced excessive extracellular matrix (ECM) formation, with similar effects to estradiol (E2), and these effects are blocked by ER antagonists. Saikosaponin D also inhibits oxidative stress-induced ROS generation and down reduates MAPK signaling pathway, and the inhibition is also suppressed by ER antagonists.

In Vivo: Saikosaponin D (2 mg/kg/day, i.p.) shows a protective effect on overdose of acetaminophen (APAP)-induced liver injury of mice. Saikosaponin D affects APAP metabolism, increases GSH levels but does not alter PPARα activation. Saikosaponin D (2 mg/kg/day, i.p.) also suppresses APAP-induced increases in the expression of STAT3 target genes and pro-inflammatory cytokines and inhibits APAP-induced activation of STAT3 and NF-kB.

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