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Methyl gallate

CAS No. : 99-24-1

MCE 国际站：Methyl gallate

产品活性：Methyl gallate是具有抗氧化，抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。Methyl gallate 还具有抗 HIV-1 和 HIV-1 酶的抑制活性。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：Bacterial  |  HIV  |  Reactive Oxygen Species

结构分类：酚类  |  多酚类

来源：植物  |  芍药科  |  芍药

In Vitro: The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H₂O₂ treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H₂O₂ (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.

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