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CAS No. : 131580-10-4
MCE 国际站:β-Amyloid (1-16)
产品活性:β-Amyloid (1-16) 是可参与金属结合的β-淀粉样蛋白片段。 β-淀粉样蛋白是在阿尔茨海默病患者的脑中形成淀粉样斑块的肽。
研究领域:Neuronal Signaling
作用靶点:Amyloid-β
In Vivo: β-amyloid (1-16) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu2+ interaction. Oxidation targets for β-Amyloid (1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aβ in senile plaque of Alzheimer’s disease with β-Amyloid (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of -Amyloid and free radical damage. β-amyloid (1-16) is the minimal amino acidic sequence display a Cu coordination mode which involves three Histidines (His6, His13 and His14). β-amyloid (1-16) is supposed to be involved in metal binding. Human β-amyloid interacts with zinc ions through its metal-binding domain 1-16. The C-tails of the two polypeptide chains of the rat Aβ(1-16) dimer are oriented in opposite directions to each other, which hinders the assembly of rat Aβ dimers into oligomeric aggregates. Thus, the differences in the structure of zinc-binding sites of human and rat β-Amyloid (1-16), their ability to form regular cross-monomer bonds, and the orientation of their hydrophobic C-tails could be responsible for the resistance of rats to Alzheimer's disease.
相关产品:THK-523 | β-Amyloid (12-28) | NIAD-4 | MAO-B-IN-9 | Ginsenoside Rg1 | Fustin | β-Amyloid (33-40) | Lecanemab | Timosaponin BII | 20(S)-Ginsenoside Rg3 | Glimepiride-d4-1 | Direct Blue 1 | PBD-150 | Rutin hydrate | Fmoc-His(3-Me)-OH | β-Amyloid (1-43)(human) | SQ-3 | Saikosaponin C | Tolcapone-d7 | Glimepiride | Crocetin monomethyl ester | CRANAD-2 | Valiltramiprosate | Acetyl-Amyloid β-Protein (1-6) amide | β-Amyloid Protein Precursor 770 (135-155) | 2-O-Acetyl-20-hydroxyecdysone | FSB | AY1511 | Birtamimab | FPS-ZM1
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