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CAS No. : 23815-87-4
MCE 国际站:Bradykinin (1-7)
产品活性:Bradykinin (1-7) 是一种氨基截短的激肽肽。Bradykinin (1-7) 是由内肽酶切割形成的一种 Bradykinin 代谢物。
研究领域:GPCR/G Protein
作用靶点:Bradykinin Receptor
In Vitro: The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8).
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Neurotransmitter Receptor Compound Library | Peptide Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Lobradimil | Fasitibant free base | Lys-[Hyp3]-Bradykinin | WIN 64338 hydrochloride | FR167344 free base | Icatibant | Lys-[Des-Arg9]Bradykinin TFA | ELN-441958 | Bombinakinin M | [Tyr8] Bradykinin | Fulimetibant | [Hyp3]-Bradykinin | [Des-Arg9]-Bradykinin acetate | Bradykinin (1-6) | Bradykinin (2-9) | Bradykinin | Bradykinin (1-5) | SSR240612 | B 9430 | MEN 11270 | Retrobradykinin | Methionyl-Lysyl-Bradykinin | Lys-[Des-Arg9]Bradykinin | Lys-Bradykinin | Deucrictibant
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