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L-(+)-Abrine

CAS No. : 526-31-8

MCE 国际站：L-(+)-Abrine

产品活性：L-(+)-Abrine 是在 Abrus precatorius 种子中发现的一种致命白蛋白，是一种急性毒性生物碱，可用作化学标记物。

研究领域：Others

作用靶点：Others

结构分类：生物碱  |  吲哚类生物碱

来源：植物  |  豆科  |  相思子

In Vitro: L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.

In Vivo: Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD₅₀ i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD₅₀ for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.

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