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CAS No. :
MCE 国际站:Adrenomedullin (1-50), rat
产品活性:Adrenomedullin (1-50), rat 是由 50 个氨基酸组成的多肽,能够通过激活 CGRP1 受体来诱导动脉血管舒张。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:CGRP Receptor
In Vitro: Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor.
In Vivo: Adrenomedullin (1-50), rat causes a dose-dependent and endothelium-independent vasodilation on the arterial mesenteric vasculature, and this effect is inhibited by CGRP1 receptor antagonist. Adrenomedullin (1-50), rat activates CGRP1 receptor in the double-perfused mesenteric bed of the rat. Adrenomedullin (1-50) ameliorates pulmonary vascular structural remodeling of hypoxic rats with incresed plasma NO and H(2)S concentrations. Adrenomedullin (1-50) also regulates the development of hypoxic pulmonary hypertension and hypoxic pulmonary vascular structural remodeling, through promoting NO and H(2)S production in hypoxic rats.
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