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CAS No. : 482-53-1
MCE 国际站:Osajin
产品活性:Osajin是 Maclura pomifera 果实中存在的主要生物活性异黄酮,具有抗肿瘤,抗氧化和抗炎活性。
研究领域:Apoptosis
作用靶点:Apoptosis
结构分类:黄酮类 | 异黄酮 | 酚类 | 多酚类
来源:植物 | 桑科 | 橙桑
In Vitro: Osajin significantly decreases the viability of human NPC cells (TW076, CG1 and TW04 cells) in a dose-dependent manner. Osajin induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress. Osajin exhibits growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells.
In Vivo: Osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemia reperfusion. This is confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function.
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