MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 33627-41-7
MCE 国际站:Inulicin
产品活性:Inulicin (1-O-Acetylbritannilactone) 是一种活性化合物,抑制 VEGF 介导的 Src 和 FAK 活化。Inulicin (1-O-Acetylbritannilactone) 还抑制 LPS 诱导的 PGE2 产生和 COX-2 表达,以及抑制 NF-κB 活化和易位。
研究领域:NF-κB | Immunology/Inflammation
作用靶点:NF-κB | COX
结构分类:萜类 | 倍半萜
来源:植物 | 豆科 | 排钱树 | 植物 | 菊科
In Vitro: Inulicin (1-O-Acetylbritannilactone) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Inulicin dose-dependently inhibits vascular endothelial growth factor (VEGF)-induced proliferation, migration, and capillary structure formation of cultured human umbilical vascular endothelial cells (HUVECs). Treatment of A549 NSCLC cells with Inulicin results in cell growth inhibition and Src-FAK in-activation. The potential effect of Inulicin is tested ton Src and FAK phosphorylation in A549 lung cancer cells. Significant high levels of Src and FAK phosphorylations are noticed a in A549 cells, which are both inhibited by treatment of Inulicin (5 μM and 10 μM). Src and FAK are both important for cancer cell proliferation. Thus, A549 cell growth, tested by MTT assay and clonogenicity assay,is remarkably inhibited by corresponding Inulicin treatment. The anti-A549 cell growth activity of Inulicin is again dose-dependent. Inulicin (1-O-Acetylbritannilactone) isolated from Inula britannica-F., inhibits inflammatory responses in vascular smooth muscle cells (VSMCs). Inulicin (5, 10, 20 μM) has several concentration dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE2 production and COX-2 expression, and blockade of NF-κB activation and translocation. In addition, Inulicin directly inhibits the binding of active NF-κB to specific DNA cis-element.
In Vivo: Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied. A single dose of Inulicin (12 mg/kg/day, i.p.) dramatically inhibits the growth of A549 xenografts in nude mice. Further, the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors. Notably, Inulicin administration does not affect mice body weights.
相关产品:Covalent Screening Library Plus | Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Highly Selective Inhibitors Library | Meloxicam-d3-1 | 4-Methylamino antipyrine hydrochloride | Vedaprofen-d3 | Pelubiprofen-13C,d3 | IMD-ferulic | Karacoline | 5-Hydroxy tryptophol β-D-glucuronide-d4 | N-tert-Butyl-α-phenylnitrone-d14 | Mangiferin | Dauricine | Tepoxalin | (rac)-AG-205 | Ampyrone | Pectolinarigenin | Ermanin | Poricoic acid A | Aceclofenac-d4 | Ginsenoside Rg1 | GS143 | SC-58125 | QNZ | 5-Aminosalicylic Acid-d3 hydrochloride | Lucyoside B | Salicylic acid-13C6 | (±)-Naproxen-d3-1 | Sulindac | Colistin adjuvant-1 | Penehyclidine | Pyrrolidinedithiocarbamate ammonium | Vanillic acid
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。