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CAS No. : 632-85-9
MCE 国际站:Wogonin
产品活性:Wogonin 是一种天然黄酮类物质,能够抑制 CDK8 和 Wnt 的活性,具有抗炎、抗肿瘤等功效。
研究领域:Cell Cycle/DNA Damage | Stem Cell/Wnt | Autophagy | Apoptosis
作用靶点:CDK | Wnt | Autophagy | Apoptosis
结构分类:黄酮类 | 黄酮 | 酚类 | 多酚类
来源:植物 | 菊科 | 百能葳 | 植物 | 唇形科
In Vitro: Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 µM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.
In Vivo: Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.
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