MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 20830-75-5
MCE 国际站:Digoxin
产品活性:Digoxin是 Na+/K+-ATPase 的有效抑制剂,有潜力用于心律失常和心力衰竭的研究。
研究领域:Membrane Transporter/Ion Channel | Metabolic Enzyme/Protease
作用靶点:Na+/K+ ATPase | Endogenous Metabolite
结构分类:甾体类 | 结构分类
来源:植物 | 其他科
In Vitro: Digoxin, a sodium-potassium ATPase inhibitor, has a negative Z score of ?26.67, suggesting a function for the sodium-potassium ATPase in CHIKV infection. Relative to DMSO-treated cells, treatment of U-2 OS cells with Digoxin results in a dose-dependent decrease in CHIKV infection with a half-maximal effective concentration (EC50) of 48.8 nM. Digoxin treatment similarly decreases CHIKV infection of primary human synovial fibroblasts (HSFs) and Vero African green monkey kidney cells with EC50s of 43.9 nM and 67.3 nM, respectively. Digoxin treatment significantly diminishes CHIKV infection in these cell types, with EC50s of 16.2 μM in ST2 cells and 23.2 μM in C2C12 cells, values 330 and 475 times the EC50 of Digoxin in U-2 OS cells. Cell viability is only modestly impaired at 24 h posttreatment with 1 μM Digoxin, a dose 20 times the Digoxin EC50 for CHIKV antiviral activity in these cells.
相关产品:D-Valine-d8 | D-α-Hydroxyglutaric acid disodium | Nicotinamide N-oxide | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | Adrenaline sulfate | Oleic acid-13C | Dextranase | H2S Donor 5a | Methylmalonic acid | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | Sphingomyelin | (-)-Jasmonoyl-L-isoleucine | Octanoic acid-d2 | Vardenafil-d5 | N-Acetyllactosamine | D-Arabitol-13C | Imidazole | L-Tartaric acid diammonium | i-Inositol | Tryptophol | L-Aspartic acid | Indolelactic acid | 6-Mercaptopurine-13C2,15N | D-Sorbitol-d8 | Octanoic acid-d3 | Dinoprost-d4
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。