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CAS No. : 41060-15-5
MCE 国际站:Neobavaisoflavone
产品活性:Neobavaisoflavone,是一种从 Psoralea corylifolia 的种子中分离出来的类黄酮。Neobavaisoflavone 具有抗炎,抗癌和抗氧化的作用。Neobavaisoflavone 在中至高浓度下可抑制 DNA 聚合酶 (DNA polymerase)。Neobavaisoflavone 也可抑制血小板聚集。
研究领域:Apoptosis | Cell Cycle/DNA Damage
作用靶点:Apoptosis | DNA/RNA Synthesis
结构分类:黄酮类 | 异黄酮 | 酚类 | 多酚类
来源:植物 | 豆科 | 补骨脂
In Vitro: Neobavaisoflavone (1-50 μM; 20 h) decreases NO (ED50=25 μM) and cytokine (ED50s=23.11, 5.03, 5.23, 5.26 and 18.80 μM for IL-1β, IL-6, IL-12p40, IL-12p70 and TNF-α, respectively) production in LPS plus IFN-γ-stimulated RAW264.7 macrophages.
Neobavaisoflavone (1-100 μM; 30 min) decreases the chemiluminescence in PMA-stimulated RAW264.7 macrophages, with an ED50 of 19.94 μM in activated RAW264.7 cells.
Neobavaisoflavone (1-100 μM); 20 h) has no effect on the viability and is not toxic to RAW264.7 cells.
Neobavaisoflavone (20-50 μM; 48 h) inhibits prostate cancer cell proliferation by inducing cytotoxicity and apoptosis in a dose-dependent manner.
Neobavaisoflavone (2-8 μM; 7 d) inhibits RANKL‐mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage.
In Vivo: Neobavaisoflavone (30 mg/kg; i.p. for 6 weeks) inhibits osteoclastogenesis, promotes osteogenesis and ameliorates bone loss in ovariectomized mice.
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