MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 63223-86-9
MCE 国际站:Ginsenoside Rh1
产品活性:Ginsenoside Rh1 (Prosapogenin A2) 抑制 PPAR-γ,TNF-α,IL-6 和 IL-1β 的表达。
研究领域:Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Apoptosis | Immunology/Inflammation | Metabolic Enzyme/Protease
作用靶点:PPAR | TNF Receptor | Interleukin Related | Endogenous Metabolite
结构分类:萜类 | 三萜
来源:植物 | 五加科 | 人参
In Vitro: The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.
In Vivo: When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Glycoside Compound Library | Lipid Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Food-Sourced Compound Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Nuclear Receptor Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Mitochondrial Protection Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | D-Valine-d8 | D-α-Hydroxyglutaric acid disodium | Nicotinamide N-oxide | Deoxycholic acid-d5 | Doxorubicin-13C,d3 TFA | Palitantin | Estradiol hemihydrate | Adrenaline sulfate | RCGD423 | Oleic acid-13C | Dextranase | H2S Donor 5a | Methylmalonic acid | Glycine, N-(aminoiminomethyl)-N-methyl-13C | Dihydroxyacetone phosphate | Sphingomyelin | (-)-Jasmonoyl-L-isoleucine | Octanoic acid-d2 | Vardenafil-d5 | Relfovetmab | N-Acetyllactosamine | D-Arabitol-13C | Imidazole | Anti-Mouse TNF alpha Antibody | L-Tartaric acid diammonium | i-Inositol | Tryptophol | L-Aspartic acid | Indolelactic acid | 6-Mercaptopurine-13C2,15N
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。