MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Amentoflavone

CAS No. : 1617-53-4

MCE 国际站：Amentoflavone

产品活性：Amentoflavone (Didemethyl-ginkgetin) 是一种有效且具有口服活性的 GABA(A) 负调节剂。Amentoflavone 还显示出抗炎、抗氧化、抗病毒、抗肿瘤、抗辐射、抗菌活性。Amentoflavone 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在亚 G1 期。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis  |  Anti-infection  |  Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Reactive Oxygen Species  |  Apoptosis  |  Bacterial  |  Fungal  |  RSV  |  GABA Receptor

结构分类：黄酮类  |  双黄酮  |  酚类  |  多酚类

来源：植物  |  卷柏科  |  卷柏

In Vitro: Amentoflavone (1-60 µM) inhibits the production of nitric oxide in a concentration-dependent manner in RAW 264.7 cells.
Amentoflavone (50-200 µM) inhibits the viability of U-87 MG cells with IC₅₀ value of 100 µM at 48 h.
Amentoflavone (0, 50, 100 µM; 48 h) induces apoptosis and cell cycle arrest at sub-G1 phase.
Amentoflavone (0, 50, 100 µM; 48 h) inhibits NF-ĸB activation and decreases the expression of MCL1 and C-FLIP protein in U-87 MG cells.
Amentoflavone (0-32 µg/ml) shows antibacterial activity with MICs of 8, 4, 32, 8, 16, 8 µg/ml for E. faecium ATCC 19434, S. aureus ATCC 25923, S. mutans ATCC 3065, E. coli O-157 ATCC 25922, E. coli ATCC 43895, P. aeruginosa ATCC 27853, respectively.

In Vivo: Amentoflavone (25 mg/kg; p.o.; once a day for 3 consecutive days) shows neuroprotective role in epilepsy via anti-inflammatory effects in mouse.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Antifungal Compound Library  |  Antibacterial Compound Library  |  Ferroptosis Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Flavonoids Library  |  Anti-Alzheimer's Disease Compound Library  |  Neuroprotective Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Mitochondria-Targeted Compound Library  |  Anti-Cancer Natural Product Library  |  Antiviral Traditional Chinese Medicine Active Compound Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  GABA Receptor Compound Library  |  Human Metabolite Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  SY-5609  |  Antifungal agent 26  |  D-α-Hydroxyglutaric acid disodium  |  Myricetin 3-O-α-L-arabinopyranoside  |  BRD4 Inhibitor-18  |  SKF89976A hydrochloride  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  (1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  Nebacumab  |  Gepotidacin  |  Amycolatopsin A  |  PC945  |  Antibiotic A-33853  |  Estradiol hemihydrate  |  AAPK-25  |  Sulbactam-d₂ sodium  |  Dutasteride-¹³C₆  |  Oleic acid-¹³C  |  Antimicrobial agent-5  |  NBTIs-IN-4  |  Proanthocyanidins  |  Anticancer agent 120  |  Azlocillin sodium salt  |  Chitin synthase inhibitor 11  |  Abacavir sulfate  |  Antitubercular agent-13  |  Meloxicam-d₃-1  |  7-Hydroxy-4-methyl-2(1H)-quinolone  |  Thailanstatin D  |  SB-218078

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。