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CAS No. : 50-22-6
MCE 国际站:Corticosterone
产品活性:Corticosterone (17-Deoxycortisol) 是一种具有口服活性的,由肾上腺皮质产生的糖皮质激素,在调节边缘系统 (包括海马体、前额叶皮层和杏仁核) 的神经元功能方面起着重要作用。皮质酮可通过 SGK 诱导的 GDI 磷酸化增加 Rab 介导的 AMPAR 膜运输。Corticosterone 还能干扰树突状细胞的成熟,具有较好的免疫抑制活性。
研究领域:Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease | Neuronal Signaling | Membrane Transporter/Ion Channel
作用靶点:Glucocorticoid Receptor | Endogenous Metabolite | iGluR
结构分类:甾体类 | 结构分类
In Vitro: Corticosterone (100 nM; 30 min) via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.
Corticosterone (CORT) (1 µM; 48 h) shows good immunosuppressive properties (functionally compromises maturation of BMDC), which impairs LPS-induced up-regulation of maturation-associated markers (MHC class II, B7.2, B7.1 and CD40).
In Vivo: Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8+ T cells in vivo.
Corticosterone (0.03 or 1 mg/kg; s.c.; single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats.
Corticosterone (2.6 mg/kg; in animal feedings; 8 days) restores ethanol intake and preference to approximately normal preoperative levels in adrenalectomy (ADX) rats.
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