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CAS No. : 2646-71-1
MCE 国际站:NADPH tetrasodium salt
产品活性:NADPH tetrasodium salt 是多种代谢和生物合成途径中的重要辅助因子 (cofactor)。NADPH tetrasodium salt 在活性分子、手性醇、脂肪酸和生物聚合物的生物合成中起着至关重要的作用,同时也是脂质生物合成、生物量形成和细胞复制所必需的。对 NADPH 的需求在增殖的癌细胞中特别高,在那里它作为核苷酸、蛋白质和脂肪酸合成的辅助因子。NADPH tetrasodium salt 对于中和代谢活性增加产生的高水平活性氧 (ROS) 也是必不可少的。NADPH tetrasodium salt 是一种内源性的 ferroptosis 抑制剂。
研究领域:Apoptosis | Metabolic Enzyme/Protease
作用靶点:Ferroptosis | Endogenous Metabolite
In Vitro: NADPH tetrasodium salt de novo synthesis is catalyzed by NAD kinases (NADKs), which catalyze the phosphorylation of NAD+ to form NADP+. NADPH tetrasodium salt is mainly involved in catabolic reactions, whereas NADPH tetrasodium salt is primarily involved in cellular antioxidative effects and anabolic reactions. NADPH tetrasodium salt is used by glutathione reductase (GR) to reduce oxidized glutathione (GSSG) to GSH.
The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth.
NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress.
NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines.
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