MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Daidzein

CAS No. : 486-66-8

MCE 国际站：Daidzein

产品活性：Daidzein 是一种大豆异黄酮，可用作 PPAR 激活剂。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor  |  Metabolic Enzyme/Protease

作用靶点：PPAR  |  Endogenous Metabolite

结构分类：黄酮类  |  异黄酮  |  酚类  |  多酚类  |  结构分类

来源：植物  |  豆科  |  大豆

In Vitro: In 3T3-L1 adipocytes, Daidzein inverses the attenuation of adiponectin gene expression by co-culture, and these effects are inhibited by the PPAR-γ specific inhibitor. Daidzein attenuates the reduction of adiponectin expression in adipocytes, and a PPAR-γ specific inhibitor abrogated this effect. Direct activation of PPAR-α and-γ by Daidzein is confirmed by a luciferase reporter assay. In HEK293T cells, Daidzein significantly increases PPAR-α transcriptional activity in a concentration-dependent manner. Although an obvious dose-dependency is not observed in PPAR-γ transcriptional activity, Daidzein also significantly increases PPAR-γ transcriptional activity over a similar range of concentrations at which Daidzein enhanced PPAR-α transcriptional activity, with a maximum increase at 25 μM. Daidzein is a soy isoflavone, which upregulates the expression of Abcg1, and it promotes axonal outgrowth in cultured hippocampal neurons via estrogen receptor signaling. Daidzein is a major component of soy with structural similarity to estrogen. It exerts an anti-inflammatory effect, lowers lipid levels, and increases mitochondrial biogenesis. As an activator of nuclear receptor peroxisome proliferator-activated receptors (PPARs), Daidzein enhances transcription of PPARs-dependent genes, including liver X receptors (LXRs, Nr1h gene family in mice). Incubation with different concentrations of Daidzein, from 5 to 100 μM, increases APOE transcriptional activity.

In Vivo: Treating Apoe KO mice with Daidzein increases Lxr and Abca1 gene expression at 1 month after stroke, showing that the absence of ApoE does not interfere with other cholesterol homeostasis genetic programs. Therefore, the findings suggest that Daidzein-induced ApoE upregulation is a critical component in fostering functional recovery in chronic stroke.

相关产品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-diabetic Compound Library  |  Lipid Compound Library  |  Endocrinology Compound Library  |  NMPA-Approved Drug Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Traditional Chinese Medicine Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Flavonoids Library  |  Anti-Obesity Compound Library  |  Transcription Factor-Targeted Library  |  Lipid Metabolism Compound Library   |  Food-Sourced Compound Library   |  Anti-Cancer Natural Product Library  |  Antidepressant Compound Library  |  Plant-Sourced Natural Product Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Nuclear Receptor Compound Library  |  Osteogenesis Compound Library  |  Cancer Stem Cells Compound Library  |  Off-patent Drug Library  |  Mitochondrial Protection Compound Library  |  Mitochondrial Toxicity Compound Library  |  D-Valine-d₈  |  D-α-Hydroxyglutaric acid disodium  |  Nicotinamide N-oxide  |  Deoxycholic acid-d₅  |  Doxorubicin-¹³C,d₃ TFA  |  Palitantin  |  Estradiol hemihydrate  |  Adrenaline sulfate  |  Oleic acid-¹³C  |  Dextranase  |  H2S Donor 5a  |  Methylmalonic acid  |  Glycine, N-(aminoiminomethyl)-N-methyl-¹³C  |  Dihydroxyacetone phosphate  |  Sphingomyelin  |  (-)-Jasmonoyl-L-isoleucine  |  Octanoic acid-d₂  |  Vardenafil-d₅  |  N-Acetyllactosamine  |  D-Arabitol-¹³C  |  Imidazole  |  L-Tartaric acid diammonium  |  i-Inositol  |  Tryptophol  |  L-Aspartic acid  |  Indolelactic acid  |  6-Mercaptopurine-¹³C₂,¹⁵N  |  D-Sorbitol-d₈  |  Octanoic acid-d₃  |  Dinoprost-d₄

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。