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CAS No. : 1476-53-5
MCE 国际站:Novobiocin sodium
产品活性:Novobiocin (Albamycin) sodium 是一种有效且具有口服活性的抗生素。Novobiocin sodium 还是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂。Novobiocin sodium 具有研究高度耐药性肺炎球菌感染的潜力。Novobiocin Sodium 具有抗正痘病毒活性。
研究领域:Anti-infection | Apoptosis | Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点:Bacterial | Antibiotic | Orthopoxvirus | Apoptosis | DNA/RNA Synthesis | HSP
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 疾病研究 | 抗炎/免疫调剂 | 抗生素 | 疾病研究 | 抗病毒 | 抗生素 | 其他类 | 结构分类
In Vitro: Novobiocin sodium (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.
Novobiocin sodium (200 µM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.
Novobiocin sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.
In Vivo: Novobiocin sodium (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.
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