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Hygromycin B

CAS No. : 31282-04-9

MCE 国际站：Hygromycin B

产品活性：Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。

研究领域：Anti-infection

作用靶点：Bacterial  |  Fungal  |  Antibiotic  |  Parasite

结构分类：抗生素  |  疾病研究  |  抗菌  |  抗生素  |  疾病研究  |  抗真菌  |  抗生素  |  其他类  |  抗生素  |  植物细胞培养  |  抗生素  |  抗性筛选  |  结构分类

In Vitro: Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Streptomyces hygroscopicus.
Hygromycin B at 0.38 mM concentration completely halts yeast cell growth in rich media, presumably by preventing protein synthesis by cytoplasmic ribosomes. Polypeptide synthesis in cell-free extracts from rabbit reticulocytes, wheat germ and yeast is strongly blocked by low concentrations ofhygromycin B. The antibiotic inhibits peptide chain elongation by yeast polysomes by preventing elongation factor EF-2-dependent translocation. The inhibition of translocation by hygromycin B might result from the stabilization of peptidyl-tRNA bound to the ribosomal acceptor site.

In Vivo: Hygromycin B inhibits protein synthesis by blocking ribosomal translocation without causing significant misreading in vivo.
?Constitutive expression of the bacterial hyg^R gene in transgenic mice in vivo confers resistance to hygromycin B.

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