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Etiocholanolone

CAS No. : 53-42-9

MCE 国际站：Etiocholanolone

产品活性：Etiocholanolone (5β-Androsterone) 是睾酮的排泄代谢物，具有抗惊厥活性。相对于其对映体形式，Etiocholanolone 是一种较弱的神经甾醇类 GABA_A receptor 正向变构调节剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：GABA Receptor  |  Endogenous Metabolite

结构分类：甾体类  |  结构分类

In Vitro: Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).

In Vivo: Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.

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