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CAS No. : 11029-61-1
MCE 国际站:Gramicidin A
产品活性:Gramicidin A 是 Gramicidin 的一种肽成分,是一种抗生素(antibiotic)的混合物,最初从 B. brevis 中分离得到。 Gramicidin A 是一种高度疏水的通道形成离子载体,在人工膜中形成一价阳离子可渗透的通道。Gramicidin A 诱导缺氧诱导因子 1α (HIF-1α) 的降解。
研究领域:Anti-infection | Metabolic Enzyme/Protease
作用靶点:Bacterial | HIF/HIF Prolyl-Hydroxylase | Antibiotic
In Vitro: Gramicidin A displays potent broad-spectrum antibiotic activity against Gram-positive strains, even multidrug-resistant strains.
Gramicidin A has the disadvantage of high hemolytic activity.
Gramicidin A (0.1 nM-10 μM, 72 h) reduces the viability of RCC cell lines and affects cell viability comparable to Monensin (HY-N4302).
Gramicidin A cellular sensitivity is significantly altered by neither VHL nor HIF-1α expression.
Gramicidin A (1 and 10 μM, 48 or 72 h) induces nonapoptotic cell death in RCC cells.
Gramicidin A (0-10 μM, 24 h) depletes cellular energy and induces metabolic dysfunction in RCC cells.
Gramicidin A (0-1 μM, 24-72 h) reduces HIF-1α and HIF-2α protein expression, reduces HIF transcriptional activity and target gene expression (24 h)
In Vivo: Gramicidin A (0.11 mg/kg; intratumoral injection; twice weekly for 14 days) inhibits the growth of RCC tumor xenografts.
Gramicidin A (0.22 mg/kg; intratumoral injection; thrice weekly for 26 days) inhibits the growth and angiogenesis of VHL-expressing RCC tumor xenografts.
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