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CAS No. : 1599441-71-0
MCE 国际站:Super-TDU
产品活性:Super-TDU 是一种特异性的 YAP 拮抗剂,可以靶向 YAP-TEAD 相互作用。Super-TDU 可以抑制胃癌小鼠模型的肿瘤生长。
研究领域:Stem Cell/Wnt
作用靶点:YAP
In Vitro: Super-TDU downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27.
In Vivo: Super-TDU (intravenous injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice.
Super-TDU (intravenous injection; 250 μg/kg 500 μg/kg) has the t1/2α of 0.78 hours and 0.82 hours; the Cmax of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.
相关产品:Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Peptide Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Highly Selective Inhibitors Library | Super-TDU (1-31) | YAP/TAZ inhibitor-1 | TDI-011536 | VT104 | AICAR | TT-10 | TED-347 | VT02956 | YTP-17 | TRULI | VT103 | MYF-01-37 | K-975 | GA-017 | YAP/TAZ inhibitor-2 | ML-7 hydrochloride | YAP-TEAD-IN-2 | DC-TEADin02 | MSC-4106 | PY-60 | Cytochalasin D | VT107 | TEAD-IN-3 | Verteporfin | TEAD-IN-2 | YAP-TEAD-IN-1
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