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CAS No. :
MCE 国际站:Pep2m, myristoylated TFA
产品活性:Pep2m, myristoylated TFA (Myr-Pep2m TFA) 是一种细胞通透性肽。Pep2m, myristoylated TFA 能破坏蛋白激酶 ζ (PKMζ) 下游靶点 NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。
研究领域:Epigenetics | TGF-beta/Smad
作用靶点:PKC
In Vitro: Pep2m, myristoylated TFA (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated TFA does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated TFA blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
In Vivo: Pep2m, myristoylated TFA (10 µg/20 µL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
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