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PACAP-38 (31-38), human, mouse, rat TFA

CAS No. :

MCE 国际站：PACAP-38 (31-38), human, mouse, rat TFA

产品活性：PACAP-38 (31-38), human, mouse, rat TFA 是一种 PAC₁ 受体激活剂。PACAP-38 (31-38), human, mouse, rat TFA 增加 α-分泌酶活性。PACAP-38 (31-38), human, mouse, rat 升高胞浆 Ca²⁺，增加细胞外调节激酶 (ERK) 和表皮生长因子受体 (EGFR) 的增殖和磷酸化。PACAP-38 (31-38), human, mouse, rat TFA 对交感神经 NPY 和儿茶酚胺的产生具有强效、持续的刺激作用。PACAP-38 (31-38), human, mouse, rat TFA 可用于神经营养和神经保护研究。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt  |  JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel

作用靶点：ERK  |  EGFR  |  Reactive Oxygen Species  |  Calcium Channel

In Vitro: PACAP-38 (31-38), human, mouse, rat TFA (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2 and ERK tyrosine phosphorylation.
PACAP-38 (31-38), human, mouse, rat TFA (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%.
PACAP-38 (31-38), human, mouse, rat TFA (10 nM; 48 h) stimulates the growth of NCI-H838 cells.
PACAP-38 (31-38), human, mouse, rat TFA (300 nM; 4 h) stimulates generation of APPsα in neural cells.
PACAP-38 (31-38), human, mouse, rat TFA (0.01-10 nM; HEK 293 cells) stimulates neural cells express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca²⁺ concentration in a dose-dependent manner with an EC₅₀ value of 0.81 nM.
PACAP-38 (31-38), human, mouse, rat TFA (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures.
PACAP-38 (31-38), human, mouse, rat TFA (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons.

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