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CAS No. : 500-65-2
MCE 国际站:Rhapontigenin
产品活性:Rhapontigenin 是白藜芦醇的天然类似物,具有抗癌,抗氧化剂,抗真菌和抗菌活性。 Rhapontigenin 是强效选择性细胞色素 P450 1A1 抑制剂 (IC50=400 nM)。Rhapontigenin 对 P450 1A1 的选择性分别是 P450 1A2 和 P450 1B1 的 400 和 23 倍。
研究领域:Metabolic Enzyme/Protease | Anti-infection
作用靶点:Cytochrome P450 | Fungal | Bacterial
结构分类:酚类 | 多酚类 | 二苯乙烯类
来源:植物 | 豆科 | 胡卢巴
In Vitro: Rhapontigenin (0-250 μM; 24 hours) demonstrates concentration-dependent anti-cancer activity with an IC50 115μM in HEP G2 cells.Rhapontigenin (20 μM; 20 hours) pre-treatment decreases TGF-β triggered increased snail expression in diverse cancer cells.Rhapontigenin (0-20 μM; 6 hours) inhibits TGF-β-induced expression of N-cadherin, vimentin, and CA9 in a dose-dependent manner.Rhapontigenin inhibits ADP- and collagen-induced platelet aggregation with IC50 values of 4 and 70 μg/ml, respectively.Rhapontigenin demonstrates a strong inhibitory activity on the 13-hexosaminidase release induced by DNP-BSA, it exhibits IC50 value of 0.03 mM in RBL 2H3 cells.
In Vivo: Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen.
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