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CAS No. : 515-13-9
MCE 国际站:β-Elemene
产品活性:β-Elemene ((-)-β-Elemene; Levo-β-elemene) 是从天然植物温郁金 (Curcuma aromatica) 中提取的,具有抗肿瘤活性。 β-Elemene ((-)-β-Elemene; Levo-β-elemene; β-Elemen) 可以诱导细胞凋亡 (apoptosis)。
研究领域:Apoptosis
作用靶点:Apoptosis
结构分类:萜类 | 倍半萜 | 结构分类
来源:植物 | 姜科 | 温郁金
In Vitro: β-Elemene (0-200 μg/ml; 24 hours) shows IC50 values of 72.8 μg/ml; 47.4 μg/ml; 61.5 μg/ml; 3.661 μg/ml; 68 μg/ml; 72.12 μg/ml; 37.894 μg/ml and 37.703 μg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively.?β-Elemene (0-75 μg/ml; 24 hours) decreases cell number from 50 μg/ml and is notably decreased at 75 μg/ml, ?induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase. ?β-Elemene (50 μg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and?p27expression in T24 cells?. ?β-Elemene (50 μg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway.
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