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CAS No. : 23800-56-8
MCE 国际站:Pogostone
产品活性:Pogostone 从广藿香油中分离出,具有抗菌和抗癌活性。 Pogostone 抑制革兰氏阴性菌和革兰氏阳性菌,也表现出对干燥杆菌的抑制作用,MIC 值为 0.098 µg /ml。 Pogostone 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。
研究领域:Anti-infection | Apoptosis | Autophagy
作用靶点:Bacterial | Apoptosis | Autophagy
结构分类:其他类 | 结构分类
来源:植物 | 菊科 | 毛连菜 | 植物 | 唇形科
In Vitro: Pogostone shows inhibitory effects on HCT116 cell with an IC50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC50: 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC50: 112±20.77 µg/ml).
In Vivo: Pogostone ( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively.
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