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CAS No. : 28282-25-9
MCE 国际站:β-Elemonic acid
产品活性:β-Elemonic acid 是从乳香树中分离得到的三萜。β-Elemonic acid 诱导细胞凋亡,活性氧 (ROS) 和 COX-2 表达,并抑制脯氨酰内肽酶。β-Elemonic acid 具有抗癌和抗炎作用。
研究领域:Apoptosis | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB
作用靶点:Apoptosis | Reactive Oxygen Species | COX | Endogenous Metabolite | Prolyl Endopeptidase (PREP)
结构分类:萜类 | 三萜
来源:植物 | 橄榄科 | 卡氏乳香树 | 植物 | 其他科
In Vitro: β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner.
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 µM.
β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase.
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.
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