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2,5-Dihydroxyacetophenone

CAS No. : 490-78-8

MCE 国际站：2,5-Dihydroxyacetophenone

产品活性：2,5-Dihydroxyacetophenone 是从熟地黄中分离出的，可通过阻断 ERK1/2 和 NF-κB 信号通路来抑制活化巨噬细胞中炎症介质的产生。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt  |  NF-κB

作用靶点：ERK  |  NF-κB

结构分类：酚类  |  多酚类  |  结构分类

来源：植物  |  玄参科  |  地黄

In Vitro: 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.

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