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Cycleanine

CAS No. : 518-94-5

MCE 国际站：Cycleanine

产品活性：Cycleanine 是一种高效的血管选择性 Ca- 拮抗剂。Cycleanine 具有缓解疼痛、肌肉松弛和抗炎作用。Cycleanine 具有通过凋亡通路发挥抗卵巢癌作用的潜力。

研究领域：Neuronal Signaling  |  Membrane Transporter/Ion Channel  |  Apoptosis

作用靶点：Calcium Channel  |  Apoptosis

结构分类：生物碱  |  生物碱二聚体

来源：植物  |  防己科  |  锡生藤

In Vitro: Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner.
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells.
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC₅₀s ranging from 7 to 14 μM.
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis).
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells.

In Vivo: Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC₅₀ of 0.8 nM.

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