MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 114-07-8
MCE 国际站:Erythromycin
产品活性:Erythromycin 是由放线菌产生的大环内酯类抗生素 (antibiotic),具有广泛的抗菌活性。Erythromycin 通过结合细菌的 50S 核糖体亚基而起作用,并通过阻断转肽和/或易位反应来抑制 RNA 依赖性蛋白 (RNA-dependent protein synthesis) 的合成,而不会影响核酸的合成。Erythromycin 在不同领域的研究中显示出抗肿瘤特性和保护神经的作用。
研究领域:Anti-infection | Cell Cycle/DNA Damage
作用靶点:Bacterial | Antibiotic | DNA/RNA Synthesis
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 疾病研究 | 抗癌 | 抗生素 | 大环内脂类 | 抗生素 | 畜牧业研究 | 抗生素 | 哺乳动物细胞培养 | 结构分类
In Vitro: Erythromycin inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively.
Erythromycin (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (p<0.01) and 8-OHdG (p<0.01), reduces Iba-1 (p<0.01) and TNF-α (p<0.01) expression significantly.
In Vivo: Erythromycin (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice.Erythromycin (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg.Erythromycin (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury.
相关产品:Covalent Screening Library Plus | Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Cell Cycle/DNA Damage Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Antiviral Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Macrocyclic Compound Library | Lipid Compound Library | Antibacterial Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Antibiotics Library | Neuroprotective Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Microbial Metabolite Library | Food-Sourced Compound Library | Rare Diseases Drug Library | Children’s Drug Library | Anti-Cancer Natural Product Library | Protein-protein Interaction Inhibitor Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Anti-Pulmonary Fibrosis Compound Library | Non-steroidal Anti-Inflammatory Compound Library | Heterocyclic Compound Library | Off-patent Drug Library | Mitochondrial Toxicity Compound Library | Myricetin 3-O-α-L-arabinopyranoside | (1R,2S,7R)-Sitafloxacin-d4 hydrochloride | Nebacumab | Doxorubicin-13C,d3 TFA | Gepotidacin | Amycolatopsin A | Antibiotic A-33853 | Estradiol hemihydrate | Sulbactam-d2 sodium | IBU-DC Phosphoramidite | Antimicrobial agent-5 | NBTIs-IN-4 | Proanthocyanidins | Anticancer agent 120 | Azlocillin sodium salt | Antitubercular agent-13 | 2,4-D sodium salt | Thailanstatin D | Toyocamycin | Lenampicillin hydrochloride | Hispolon | PC58538 | Carboplatin-d4 | SPR206 acetate | Caracemide | Antimicrobial agent-10 | Doxycycline calcium | Farudodstat | Antibacterial agent 138 | Staurosporine
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。