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CAS No. : 616-91-1
MCE 国际站:Acetylcysteine
产品活性:Acetylcysteine (N-Acetylcysteine) 是一种粘液溶解剂 (mucolytic agent),可用于减少粘液的厚度。Acetylcysteine 是一种 ROS 抑制剂。Acetylcysteine 是半胱氨酸前体,通过中和花生四烯酸依赖的5-脂氧合酶活性所产生的毒性脂质来防止血红素诱导的铁中毒 (ferroptosis)。Acetylcysteine 可以诱导细胞凋亡 (apoptosis),并具有抗流感病毒活性。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis | Anti-infection
作用靶点:Reactive Oxygen Species | Endogenous Metabolite | Apoptosis | Ferroptosis | Influenza Virus
结构分类:酮、醛、酸 | 结构分类
In Vitro: Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons.Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism.
In Vivo: Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group Acetylcysteine 300 mg/kg. Lung glutathione peroxidase is significantly increases in group Acetylcysteine 300 mg/kg(P=0.04), while the other oxidation biomarkers show no significant differences.Acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.
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