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Oxytetracycline

CAS No. : 79-57-2

MCE 国际站：Oxytetracycline

产品活性：Oxytetracycline 是一种属于四环素类的抗生素。Oxytetracycline 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline 还具有抗 HSV-1 的活性。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Bacterial  |  HSV  |  Endogenous Metabolite  |  Antibiotic

结构分类：抗生素  |  疾病研究  |  抗菌  |  酚类  |  单酚类  |  抗生素  |  其他类  |  抗生素  |  种植业研究  |  抗生素  |  畜牧业研究  |  抗生素  |  抗性筛选  |  结构分类

In Vitro: Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

In Vivo: The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

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