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CAS No. : 313-67-7
MCE 国际站:Aristolochic acid A
产品活性:Aristolochic acid A (Aristolochic acid I; TR 1736) 是植物提取物 Aristolochic acids 的主要成分,其存在于 Aristolochia 和 Asarum 草本植物中。Aristolochic acid A 显着降低激活蛋白1 (AP-1) 和 NF-κB 活性。Aristolochic acid A 降低人细胞中膀胱癌相关 BLCAP 基因表达。
研究领域:NF-κB
作用靶点:NF-κB
结构分类:生物碱 | 结构分类
来源:植物 | 马兜铃科 | 马兜铃 | 植物 | 其他科
In Vitro: Aristolochic acid A (150, 200 μM, 24?hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2.
?Aristolochic acid A (100, 200 μM, 24?hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376).
?Aristolochic acid A (100, 200 μM, 24?hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells.
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