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Licochalcone D

CAS No. : 144506-15-0

MCE 国际站：Licochalcone D

产品活性：Licochalcone D 是存在于 Glycyrrhiza uralensis 中的黄酮类化合物，是具有口服活性的 NF-κB p65 的有效抑制剂。Licochalcone D 具有抗氧化、抗炎、抗癌等作用。

研究领域：NF-κB  |  Apoptosis  |  Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：NF-κB  |  Apoptosis  |  Reactive Oxygen Species

结构分类：黄酮类  |  查耳酮  |  酚类  |  多酚类

来源：植物  |  豆科  |  甘草

In Vitro: Licochalcone D (10 μM; 1 h) negatively regulates Lipopolysaccharides (LPS) (HY-D1056)-induced NF-κB activation by inhibiting the phosphorylation and transactivation of NF-κB p65, inhibits the LPS-induced activation of protein kinase A (PKA), and significantly inhibits the LPS-induced expression of TNFα and MCP-1.
Licochalcone D (10 μM; 24 h) significantly inhibits LPS-induced iNOS expression and NO production.
Licochalcone D (0-90 μM; 24 h) inhibits the proliferation of human melanoma cells, induces the apoptosis of A375 cells, decreases the mitochondrial membrane potential and increases ROS production in A375 cells.
Licochalcone D (0-25 μM; 24 h) decreases the migration and invasion ability of the A375 cells, decreased the protein levels of MMP-2 and MMP-9.

In Vivo: Licochalcone D (25 and 50 mg/kg; i.g.; daily for a week) inhibits the tumor growth in a mouse xenograft model of murine melanoma B16F0 cells.

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