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Nicotinamide riboside chloride

CAS No. : 23111-00-4

MCE 国际站：Nicotinamide riboside chloride

产品活性：Nicotinamide riboside Chloride 是具有口服活性的 NAD⁺ 的前体，增加 NAD⁺ 水平并激活 SIRT1 和 SIRT3。Nicotinamide riboside Chloride 是维生素 B3 (烟酸) 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。Nicotinamide riboside Chloride 可以减少阿尔茨海默氏病转基因小鼠模型中的认知退化。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Metabolic Enzyme/Protease

作用靶点：Sirtuin  |  Endogenous Metabolite

结构分类：生物碱  |  吡啶类生物碱  |  结构分类

In Vitro: Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.
Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD⁺ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.
Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.

In Vivo: Chronic Nicotinamide riboside Chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD⁺ content in a tissue-specific manner.

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