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CAS No. : 572-30-5
MCE 国际站:Avicularin
产品活性:Avicularin 是一种具有口服活性的黄酮类化合物。Avicularin 抑制 NF-κB (p65) , COX-2 和 PPAR-γ 的活性。Avicularin 具有抗炎、抗感染、抗过敏、抗氧化、保肝、抗肿瘤等作用。
研究领域:Immunology/Inflammation | NF-κB | Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Stem Cell/Wnt | MAPK/ERK Pathway | Membrane Transporter/Ion Channel | Apoptosis
作用靶点:COX | NF-κB | PPAR | ERK | GLUT | Apoptosis
结构分类:黄酮类 | 黄酮醇 | 酚类 | 多酚类
来源:植物 | 樟科 | 乌药
In Vitro: Avicularin (10-300 μM, 1 h) suppresses NO and PGE2 production in LPS-stimulated RAW 264.7 cells.
Avicularin (10-300 μM, 1 h) exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 cells.
Avicularin (25-100 μg/mL, 48 h) decreases cell proliferation, cell migration and invasion in Huh7 cells.
Avicularin (25-100 μg/mL, 48 h) induces apoptosis via the downregulation of NF‑κB (p65) and COX‑2 and the upregulation of PPAR‑γ.
Avicularin (50 μM, 6 days) decreases the intracellular lipids, along with decreased PPARγ, C/EBPα, and aP2 mRNA levels in 3T3-L1 cells.
Avicularin (50 μM, 6 days) suppresses GLUT4-Mediated glucose uptake in 3T3-L1 cells.
Avicularin (2.5-10 μM, 2 h) inhibits ECM degradation and inflammation via TRAF6/MAPK activation in rat and human chondrocytes.
In Vivo: Avicularin (injected in articular cavity of the knee, 0.5-2 mg/kg, twice a week for 4 weeks) attenuates the development of OA (osteoarthritis) in ACLT-induced rats.
Avicularin (oral administration, 50 and 100 mg/kg, for 21 days) attenuates memory Impairment in rats with amyloid Beta-induced Alzheimer's disease.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Membrane Transporter/Ion Channel Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Glycoside Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Phenols Library | Glycolysis Compound Library | Pyroptosis Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Alzheimer's Disease Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Glucose Metabolism Compound Library | Food-Sourced Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | Osteogenesis Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | SY-5609 | BRD4 Inhibitor-18 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | AAPK-25 | Dutasteride-13C6 | Oleic acid-13C | Anticancer agent 120 | Abacavir sulfate | Meloxicam-d3-1 | 4-Methylamino antipyrine hydrochloride | Thailanstatin D | SB-218078 | Vedaprofen-d3 | Toyocamycin | Sorafenib-d4 | Pelubiprofen-13C,d3 | IMD-ferulic | Busulfan | Karacoline | PTC-028 | 5-Hydroxy tryptophol β-D-glucuronide-d4 | Dinaciclib | CR-1-31-B | 142I5 | Farudodstat | Ecteinascidin 770 | AT9283 | Staurosporine | SNS-032 | N-tert-Butyl-α-phenylnitrone-d14
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
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