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CAS No. :
MCE 国际站:Calcitonin Gene Related Peptide (CGRP) II, rat TFA
产品活性:Calcitonin Gene Related Peptide (CGRP) II, rat TFA,一种 CGRP 受体 (CGRP receptors) 激活剂,是一种有效且持久的血管扩张剂。Calcitonin Gene Related Peptide (CGRP) II, rat TFA 可用于心血管疾病的研究。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:CGRP Receptor
In Vitro: Calcitonin Gene Related Peptide (CGRP) II, rat TFA induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM.
Calcitonin Gene Related Peptide (CGRP) II, rat TFA relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM.
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor).
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately.
In Vivo: Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats.
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