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Isobavachalcone

CAS No. : 20784-50-3

MCE 国际站：Isobavachalcone

产品活性：Isobavachalcone (Corylifolinin) 来源于补骨脂，是一种 Akt 信号通路的有效抑制剂，可诱导人类癌细胞凋亡 (以 IC₅₀ 值为 7.92 μM 抑制 OVCAR-8 癌细胞生长)，具有抗癌和抗增殖活性。Isobavachalcone 还能诱导 OVCAR-8 细胞中活性氧的产生。

研究领域：PI3K/Akt/mTOR  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB  |  Apoptosis  |  Autophagy

作用靶点：Akt  |  Reactive Oxygen Species  |  Apoptosis  |  Autophagy

结构分类：黄酮类  |  查耳酮  |  酚类  |  多酚类  |  结构分类

来源：植物  |  豆科  |  补骨脂

In Vitro: Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC₅₀ values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively.
Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation.
Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway.

In Vivo: Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing.

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