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Cabazitaxel

CAS No. : 183133-96-2

MCE 国际站：Cabazitaxel

产品活性：Cabazitaxel 是天然紫杉烷脱乙酰基巴卡丁III 的半合成衍生物，具有显著的抗肿瘤功效。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton  |  Autophagy

作用靶点：Microtubule/Tubulin  |  Autophagy

结构分类：其他类

来源：植物  |  红豆杉科  |  红豆杉  |  植物  |  八角科  |  红豆杉

In Vitro: The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%.

In Vivo: Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group.

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